Lilemong tsa bo-1990, Pfizer o ile a etella pele ho nts'etsapele le ho thathamisa sehlahisoa sa pele sa lefats'e sa khetla ea capsule e seng gelatin, thepa e tala ea eona e leng cellulose ester "hydroxypropyl methyl cellulose" ho tsoa limela.Hobane mofuta ona o mocha oa capsule ha o na lisebelisoa leha e le life tsa liphoofolo, e rorisoa ke indasteri e le "capsule ea semela".Hona joale, le hoja palo ea thekiso ea li-capsules tsa semela 'marakeng oa machaba oa capsule ha e phahame, tsoelo-pele ea eona e matla haholo, e nang le sebaka se pharaletseng sa kholo ea' maraka.
　　
"Ka tsoelo-pele ea saense ea bongaka le thekenoloji le saense e amanang le eona, bohlokoa ba li-excipients tsa meriana ha ho etsoa litokisetso tsa meriana bo 'nile ba hlokomeloa butle-butle,' me boemo ba k'hemistri bo ntse bo eketseha."Ouyang Jingfeng, mofuputsi ea amanang le Setsi sa Setsi sa Sechaena sa Setsi sa Bongaka sa China, o bontšitse hore li-excipients tsa meriana ha li bone feela boleng ba mefuta e mecha ea litekanyetso le litokisetso tse ncha tsa lithethefatsi ho isa tekanyong e kholo, empa hape li thusa boitokisetso ba ho theha, ho tsitsisa, ho qhibiliha. , eketsa solubilize, eketsa tokollo, tokollo e tsitsitseng, tokollo e laoloang, tlhophiso, nako, boemo, ts'ebetso e potlakileng, e sebetsang hantle le e nkang nako e telele, 'me ka tsela e itseng, nts'etsopele ea mothusi e mocha ea khabane e ka lebisa nts'etsopele ea sehlopha se seholo. ea mefuta ea litekanyetso, ho ntlafatsa boleng ba palo e kholo ea meriana e mecha le litokisetso, 'me bohlokoa ba eona bo feta hole nts'etsopele ea moriana o mocha.Mefuteng ea litekanyetso tsa meriana tse kang lipilisi tsa tranelate, matlapa, liente le li-capsules, li-capsules li fetohile mefuta e ka sehloohong ea litekanyetso tsa litokisetso tse tiileng tsa molomo ka lebaka la bioavailability ea tsona e phahameng, ho ntlafatsa botsitso ba lithethefatsi, le boemo ba nako le ho lokolloa ha lithethefatsi.

Hona joale, thepa e ka sehloohong e tala bakeng sa tlhahiso ea li-capsules ke gelatin, gelatin e entsoe ka hydrolysis ea masapo le matlalo a liphoofolo, 'me ke macromolecule ea likokoana-hloko e nang le sebopeho sa ternary spiral, se nang le biocompatibility e ntle le thepa ea' mele le ea lik'hemik'hale.Leha ho le joalo, li-capsules tsa gelatin le tsona li na le mefokolo e itseng ha li sebelisoa, 'me nts'etsopele ea lisebelisoa tse ncha bakeng sa likhetla tsa capsule tsa tlhaho e seng ea liphoofolo e se e le sebaka se chesang lipatlisisong tsa morao-rao tsa li-excipients tsa meriana.Wu Zhenghong, moprofesa Univesithing ea China Pharmaceutical, o boletse hore ka lebaka la "lefu la bohlanya ba likhomo" linaheng tsa Europe tse kang britain, Fora le Netherlands lilemong tsa bo-1990 (ho kenyeletsoa le Japane e Asia, e ileng ea boela ea fumana likhomo tse hlanyang tse nang le lefu la bohlanya ba likhomo) , batho ba linaha tsa Bophirimela ba ne ba e-na le ho se tšepe nama ea nama ea likhomo le likhomo tse amanang le likhomo (gelatin le eona ke e ’ngoe ea tsona).Ho feta moo, Mabuddha le batho ba jang meroho le bona ba hanana le li-capsules tsa gelatin tse entsoeng ka thepa e tala ea liphoofolo.Ka lebaka la sena, lik'hamphani tse ling tsa kantle ho naha li ile tsa qala ho ithuta lisebelisoa tse ncha bakeng sa likhetla tsa capsule tsa li-gelatin le mehloli e meng ea liphoofolo, 'me puso ea li-capsules tsa setso tsa gelatin e ile ea qala ho thekesela.

Ho fumana lisebelisoa tse ncha tsa ho lokisa li-capsules tse seng tsa gelatin ke tataiso ea hajoale ea nts'etsopele ea li-excipients tsa meriana.Ouyang Jingfeng o bontšitse hore lisebelisoa tse tala tsa li-capsules tsa semela hona joale ke hydroxypropyl methylcellulose, starch e fetotsoeng le li-glues tsa lijo tsa hydrophilic polymer, tse kang gelatin, carrageenan, xanthan gum joalo-joalo.Li-capsules tsa Hydroxypropyl methyl cellulose li na le solubility e tšoanang, ho arohana le bioavailability ho li-capsules tsa gelatin, ha li ntse li e-na le melemo e meng eo li-capsules tsa gelatin li se nang eona, empa ts'ebeliso ea hona joale e ntse e se e pharaletseng haholo, haholo-holo ka lebaka la theko e phahameng ea sehlahisoa, ha e bapisoa le gelatin. Theko ea thepa e tala ea hydroxypropyl methyl cellulose capsule e phahame, ntle le lebelo le liehang la gel, e bakang potoloho e telele ea tlhahiso.

Mmarakeng oa lefats'e oa meriana, li-capsules tsa semela ke e 'ngoe ea lihlahisoa tse holang ka potlako.Wu Zhenghong o boletse hore ha ho bapisoa le li-capsules tsa gelatin, li-capsules tsa semela li na le melemo e latelang e totobetseng: Ea pele, ha ho na karabelo e kopanyang.Li-capsules tsa limela li na le inertness e matla 'me ha ho bonolo ho tšela lihlopha tsa aldehyde kapa metsoako e meng.Ea bobeli e loketse lithethefatsi tse thibelang metsi.Mongobo oa li-capsules tsa semela ka kakaretso o laoloa pakeng tsa 5% le 8%, 'me ha ho bonolo ho itšoara ka lik'hemik'hale le likahare,' me metsi a tlaase a tiisa botsitso ba litaba tsa hygroscopic tse ka hlaseloang habonolo ke mongobo.Ea boraro ke ho lumellana hantle le li-excipients tse ka sehloohong tsa meriana.Li-capsules tsa meroho li lumellana hantle le lactose, dextrin, starch, microcrystalline cellulose, magnesium stearate le lisebelisoa tse ling tse sebelisoang haholo tsa meriana.Ea bone ke ho ba le sebaka se phutholohileng sa ho tlatsa.Li-capsules tsa limela li na le litlhoko tse batlang li hlephile bakeng sa tikoloho ea ho sebetsa ea litaba tse tlatsitsoeng, ebang ke litlhoko tsa tikoloho ea ho sebetsa kapa tekanyo ea ho feta mochine, e ka fokotsang litšenyehelo tsa tšebeliso.
　
　
"Lefatšeng, li-capsules tsa limela li ntse li le lilemong tsa bona, ke likhoebo tse fokolang haholo feela tse ka hlahisang li-capsules tsa meriana ea limela, 'me hoa hlokahala ho matlafatsa lipatlisiso ka mekhoa ea tlhahiso le likarolo tse ling, ha ho ntse ho eketsa boiteko ba ho phahamisa maraka."Ouyang Jingfeng o bontšitse hore hajoale, tlhahiso ea li-capsules tsa gelatin naheng ea China e fihlile sebakeng sa pele lefatšeng, ha karolo ea 'maraka ea lihlahisoa tsa li-capsule tsa semela e ntse e le tlase.Ho phaella moo, hobane mokhoa oa ho hlahisa li-capsules ha o e-s'o fetohe ka lilemo tse fetang lekholo, 'me ntlafatso e tsoelang pele ea lisebelisoa e etselitsoe ho latela mokhoa oa tlhahiso ea gelatin, mokhoa oa ho sebelisa mokhoa le lisebelisoa tsa ho lokisetsa li-capsules tsa gelatin ho lokisetsa semela. Li-capsules e se e le sepheo sa lipatlisiso, se kenyelletsang thuto e khethehileng ea likarolo tsa ts'ebetso tse kang viscosity, thepa ea rheological le viscoelasticity ea thepa.
　　

Le hoja ho sa khonehe hore li-capsules tsa semela li nke sebaka sa puso ea li-capsules tse se nang letho tsa gelatin, li-capsules tsa semela li na le melemo e totobetseng ea tlhōlisano litokisetsong tsa meriana ea setso ea Chaena, litokisetso tsa likokoana-hloko le lijo tse sebetsang hantle.Zhang Youde, moenjiniere e moholo Sekolong sa Saense ea Lintho le Boenjiniere sa Setsi sa Theknoloji sa Beijing, o lumela hore ka kutloisiso e tebileng ea batho ea li-capsules tsa limela le phetoho ea maikutlo a sechaba a lithethefatsi, tlhokahalo ea 'maraka ea li-capsules tsa limela e tla hōla ka potlako.